Publications 2003 - 2007

Switching on the lights for gene therapy.

Winkeler A, Sena-Esteves M, Paulis LE, Li H, Waerzeggers Y, Rückriem B, Himmelreich U, Klein M, Monfared P, Rueger MA, Heneka M, Vollmar S, Hoehn M, Fraefel C, Graf R, Wienhard K, Heiss WD, Jacobs AH.
PLoS One. 2007 Jun 13;2(6):e528

Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector.

Kummer C, Winkeler A, Dittmar C, Bauer B, Rueger MA, Rueckriem B, Heneka MT, Vollmar S, Wienhard K, Fraefel C, Heiss WD, Jacobs AH.
Mol Imaging. 2007 May-Jun;6(3):181-92

HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation.

Saydam O, Saydam N, Glauser DL, Pruschy M, Dinh-Van V, Hilbe M, Jacobs AH, Ackermann M, Fraefel C.
Gene Ther. 2007 Aug;14(15):1143-51. Epub 2007 May 10

Integration of active human beta-galactosidase gene (100 kb) into genome using HSV/AAV amplicon vector.

Oehmig A, Cortés ML, Perry KF, Sena-Esteves M, Fraefel C, Breakefield XO.
Gene Ther. 2007 Jul;14(14):1078-91. Epub 2007 Apr 26

Live covisualization of competing adeno-associated virus and herpes simplex virus type 1 DNA replication: molecular mechanisms of interaction.

Glauser DL, Strasser R, Laimbacher AS, Saydam O, Clément N, Linden RM, Ackermann M, Fraefel C.
J Virol. 2007 May;81(9):4732-43. Epub 2007 Feb 21

Imaging-guided gene therapy of experimental gliomas.

Jacobs AH, Rueger MA, Winkeler A, Li H, Vollmar S, Waerzeggers Y, Rueckriem B, Kummer C, Dittmar C, Klein M, Heneka MT, Herrlinger U, Fraefel C, Graf R, Wienhard K, Heiss WD.
Cancer Res. 2007 Feb 15;67(4):1706-15

Gene Delivery using HSV/AAV Hybrid Amplicon Vectors.
Saydam O., D.L. Glauser and C. Fraefel
In: Friedman T. and J. Rossi. Gene Delivery/Gene Transfer Manual. Cold Spring Harbor Laboratory Press. Woodbury, NY. 265-270 (2007)

Chimeric Herpes Simplex Virus/Adeno-Associated Virus Amplicon Vectors.
Glauser, D.L., M. Ackermann, O. Saydam and C. Fraefel
Curr. Gene Ther. 6:315-324 (2006)

Parvovirus replication.
Glauser D.L., O. Saydam and C. Fraefel
In: Hefferon K.L. Recent Advances in DNA virus replication. Research Signpost, Kerala, India, 71-99 (2006).

HSV amplicon vectors for gene delivery to the nervous system.
Senn C., C. Fraefel, and X.O. Breakefield
In: Kaplitt M. and M. During. Gene Therapy of the nervous system: from bench to bedside. Elsevier, Amsterdam. 25-43 (2006).

Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins.

Glauser DL, Saydam O, Balsiger NA, Heid I, Linden RM, Ackermann M, Fraefel C.
J Virol. 2005 Oct;79(19):12218-30

Herpes simplex virus 1 envelopment follows two diverse pathways.

Leuzinger H, Ziegler U, Schraner EM, Fraefel C, Glauser DL, Heid I, Ackermann M, Mueller M, Wild P.
J Virol. 2005 Oct;79(20):13047-59

Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo.

Saydam O, Glauser DL, Heid I, Turkeri G, Hilbe M, Jacobs AH, Ackermann M, Fraefel C.
Mol Ther. 2005 Nov;12(5):803-12. Epub 2005 Aug 22

Herpes simplex virus type-1 amplicon vectors for vaccine generation in acute lymphoblastic leukemia.

Zibert A, Thomassen A, Müller L, Nguyen L, Glouchkova L, Fraefel C, Roskrow M, Meisel R, Dilloo D.
Gene Ther. 2005 Dec;12(23):1707-17

In vivo gene transfer to the rat retina using herpes simplex virus type 1 (HSV-1)-based amplicon vectors.

Fraefel C, Mendes-Madeira A, Mabon O, Lefebvre A, Le Meur G, Ackermann M, Moullier P, Rolling F.
Gene Ther. 2005 Aug;12(16):1283-8

Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors.

Rueger MA, Winkeler A, Miletic H, Kaestle C, Richter R, Schneider G, Hilker R, Heneka MT, Ernestus RI, Hampl JA, Fraefel C, Jacobs AH.
Gene Ther. 2005 Apr;12(7):588-96

Gene transfer into hepatocytes mediated by herpes simplex virus-Epstein-Barr virus hybrid amplicons.

Müller L, Saydam O, Saeki Y, Heid I, Fraefel C.
J Virol Methods. 2005 Jan;123(1):65-72

Spatial and temporal organization of adeno-associated virus DNA replication in live cells.

Fraefel C, Bittermann AG, Büeler H, Heid I, Bächi T, Ackermann M.
Virol. 2004 Jan;78(1):389-98

Herpes simplex virus type 1 amplicons and their hybrid virus partners, EBV, AAV, and retrovirus.
Oehmig A., C. Fraefel, X.O. Breakefield and M. Ackermann
Curr. Gene Ther. 4:385-408 (2004)

Update on herpesvirus amplicon vectors.
Oehmig A, C. Fraefel and X.O. Breakefield
Mol. Ther. 10:630-643 (2004)

Construction of HSV-1 BACs and their use for packaging of HSV-1-based amplicon vectors.
Heister T.G., A. Vogtlin, L. Muller, I. Heid and C. Fraefel
Methods Mol. Biol. 256:241-256 (2004)

Mehr als nur Fieberbläschen: Herpes Simplex Viren im Dienste der Gesundheit
Müller L. und C. Fraefel.
Vierteljahresschrift der Naturforschenden Gesellschaft Zürich 149 (4): 87-94 (2004). Review

HSV/AAV hybrid vectors.
Fraefel C., T. Heister and M. Ackermann
Gene Ther. Regul. 2:7-28 (2003)

Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectorsBreakefield X.O., E.A. Chiocca, Y. Saeki, C. Fraefel, K. Tobler, M. Ackermann, M. Suter, G.J. Adema and K. Shortman
(2003) Unites tates Patent 6,573,090

One giant genomic leap for gene transfer technology.
Ackermann M. and C. Fraefel
Mol. Ther. 7:571 (2003). Commentary