Publications 1992 - 1997

Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors
Fraefel C., D.R. Jacoby, C. Lage, H. Hilderbrand, J.Y. Chou, F.W. Alt, X.O. Breakefield and J.A. Majzoub
Mol. Med. 1997 Dez;3(12):813-25 PMCID: PMC2230287

Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo.Aboody-Guterman KS, Pechan PA, Rainov NG, Sena-Esteves M, Jacobs A, Snyder EY, Wild P, Schraner E, Tobler K, Breakefield XO, Fraefel C.
Neuroreport. 1997 Dec 1;8(17):3801-8

HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells.
Johnston KM, Jacoby D, Pechan PA, Fraefel C, Borghesani P, Schuback D, Dunn RJ, Smith FI, Breakefield XO.
Hum Gene Ther. 1997 Feb 10;8(3):359-70

Helper virus-free herpes simplex virus-1 plasmid vectors for gene therapy of Parkinson’s Disease and other neurodegenerative disorders.
Geller A.I., L. Yu, Y. Wang and C. Fraefel
Exp. Neurol. 1997 Mar;144(1):98-102 (1997) doi: 10.1006/exnr.1996.6394

Hybrid vectors: a new generation of virus-based vectors designed to control the cellular fate of delivered genes
Jacoby D., C. Fraefel and X.O. Breakefield
Gene Therapy 1997 Dec;4(12):1281-1283 (1997). doi: 10.1038/sj.gt.3300578

Recombinant bovine herpesvirus-1 (BHV-1) lacking transactivator protein BICPO entails lack of glycoprotein C and severely reduced infectivity.Köppel R, Fraefel C, Vogt B, Bello LJ, Lawrence WC, Schwyzer M.
Biol Chem. 1996 Dec;377(12):787-95

Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells.
Fraefel C, Song S, Lim F, Lang P, Yu L, Wang Y, Wild P, Geller AI.
J Virol. 1996 Oct;70(10):7190-7

A method to codetect introduced genes and their products in gene therapy protocols.
Gussoni E, Wang Y, Fraefel C, Miller RG, Blau HM, Geller AI, Kunkel LM.
Nat Biotechnol. 1996 Aug;14(8):1012-6

Identification and characterization of BICP27, an early protein of bovine herpesvirus 1 which may stimulate mRNA 3' processing.Singh M, Fraefel C, Bello LJ, Lawrence WC, Schwyzer M.
J Gen Virol. 1996 Apr;77 ( Pt 4):615-25

Identification of the bovine herpesvirus 1 circ protein, a myristylated and virion-associated polypeptide which is not essential for virus replication in cell culture.Fraefel C, Ackermann M, Schwyzer M.
J Virol. 1994 Dec;68(12):8082-8

BICP22 of bovine herpesvirus 1 is encoded by a spliced 1.7 kb RNA which exhibits immediate early and late transcription kinetics.Schwyzer M, Wirth UV, Vogt B, Fraefel C.
J Gen Virol. 1994 Jul;75 ( Pt 7):1703-11

Identification and zinc dependence of the bovine herpesvirus 1 transactivator protein BICP0.Fraefel C, Zeng J, Choffat Y, Engels M, Schwyzer M, Ackermann M.
J Virol. 1994 May;68(5):3154-62

Methods to investigate the expression of lignin peroxidase genes by the white rot fungus Phanerochaete chrysosporium.Reiser J, Walther IS, Fraefel C, Fiechter A.
Appl Environ Microbiol. 1993 Sep;59(9):2897-903

Promoter, spliced leader, and coding sequence for BICP4, the largest of the immediate-early proteins of bovine herpesvirus 1.Schwyzer M, Vlcek C, Menekse O, Fraefel C, Paces V.
Virology. 1993 Nov;197(1):349-57

Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: the circ gene.Fraefel C, Wirth UV, Vogt B, Schwyzer M.
J Virol. 1993 Mar;67(3):1328-33

Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are 3' coterminal and encode a putative zinc finger transactivator protein.Wirth UV, Fraefel C, Vogt B, Vlcek C, Paces V, Schwyzer M.
J Virol. 1992 May;66(5):2763-72