Publications 2020 - 2025

The influence of the cytoskeleton on the development and behavior of viral factories in mammalian orthoreovirus
Melissa Lee, Janine Vetter, Catherine Eichwald
Virology, Volume 604, March 2025, 110423 doi.org/10.1016/j.virol.2025.110423

Adeno-associated virus (AAV2) can replicate its DNA by a rolling Hairpin or rolling circle mechanism, depending on the helper virus.
Anouk Lkharrazi, Kurt Tobler, Sara Marti, Anna Bratus-Neuenschwander, Bernd Vogt, Cornel Fraefel
J Virol. 2024 Oct 09:e0097524.doi: 10.1128/jvi.01282-24

Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across rotavirus species A to J
Melissa Lee, Ariana Cosic, Kurt Tobler, Claudio Aguilar, Cornel Fraefel, Catherine Eichwald
J Virol. 2024 Aug 28:e0097524.doi: 10.1128/jvi.00975-24

The interferon-γ inducible factor 16 (IFI16) restricts adeno-associated virus serotype 2 (AAV2) transduction in an immune-modulatory independent way
Sereina Sutter, Kurt Tobler, Michael Seyffert, Anouk Lkharrazi, Joël Zöllig, Elisabeth M. Schraner, Bernd Vogt, Hildegard Büning, Cornel Fraefel
J Virol 2024 Jul 23;98(7):e0011024. doi: 10.1128/jvi.00110-24

Antibody reactions of horses against various domains of the EHV-1 receptor-binding progein gD1
Andreina Schramm, Mathias Ackermann, Catherine Eichwald, Claudio Aguilar, Cornel Fraefel, Julia Lechmann
2024 Jul 12; 19(7):e0301987. doi: 10.1371/journal.pone.0301987.eCollection 2024.

The Role of the Host Cytoskeleton in the Formation and Dynamics of Rotavirus Viroplasma
Janine Vetter, Melissa Lee, Catherine Eichwald
Viruses 2024, 16(5), 668; https://doi.org/10.3390/v16050668 (registering DOI)

The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
Janine Vetter, Guido Pap, Kurt Tobler, Javier M. Rodriguez, Manuel Kely, Michael Myers, Mahesa Wiesendanger, Elisabeth M. Schraner, Daniel Luque, Oscar R. Burrone, Cornel Fraefel, Catherine Eichwald
mBio2024 Vol. 15, No.4 Mar 12:e0049924.doi: 10.1128/mbio.00499-24

Genome Sequence of Alongshan Virus from Ixodes ricinus Ticks Collected in Switzerland
Stefanie Stegmüller, Cornel Fraefel, Jakuk Kubacki
Microbiol Resour Announc2023 Mar 16;12(3):e0128722.doi: 10.1128/mra.01287-22.

Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens
Stefanie Stegmüller, Weihong Qi, Paul R. Torgerson, Cornel Fraefel, Jakub Kubacki
PLoS One. 2023 Nov 13;18(11):e0290942.doi: 10.1371/journal.pone.0290942. eCollection 2023.

Cellular state landscape and herpes simplex virus type 1 infection progression are connected
Maija Pietilä, Jana J. Bachmann, Janne Ravantti, Lucas Pelkmans, Cornel Fraefel
Nat Commun. 2023 Jul 27;14(1):4515.doi: 10.1038/s41467-023-40148-6.

TiO₂ nanoparticles abrogate the protective effect of the Crohn's disease-associated variation within the PTPN22 gene locusMarlene Schwarzfischer, Anna Niechcia, Kristina Handler, Yasser Morsy^, Marcin Wawrzyniak , Andrea S Laimbacher , Kirstin Atrott , Roberto Manzini, Katharina Baebler, Larissa Hering, Egle Katkeviciute, Janine Häfliger, Silvia Lang, Maja E Keller, Jérôme Woodtli, Lisa Eisenbeiss, Thomas Kraemer, Elisabeth M Schraner, Mahesa Wiesendanger, Sebastian Zeissig, Gerhard Rogler, Andreas E Moor, Michael Scharl, Marianne R Spalinger
Gut.2022 Oct 3;gutjnl-2021-325911.doi: 10.1136/gutjnl-2021-325911.

Fully automated dried blood spot sample handling and extraction for BoHV-1 antibody testing by ELISA
Julia Lechmann, Oliver Gehrig, Marc Luginbühl, Cornel Fraefel, Stefan Gaugler
J Virol Methods.2022 Sep 28;310:114626.doi:10.1016/j.jviromet.2022.114626.

Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin FilamentsJanine Vetter, Guido Papa, Michael Seyffert, Kapila Gunasekera, Giuditta De Lorenzo, Mahesa Wiesendanger, Jean-Louis Reymond, Cornel Fraefel, Oscar R Burrone, Catherine Eichwald
J Virol. 2022 Sep 14;96(17):e0107422.doi: 10.1128/jvi.01074-22. Epub 2022 Aug 8.

Multiplex real-time PCR for the detection and differentiation of equid gammaherpesvirus 2 and 5
Flavia Fürer, Cornel Fraefel, Julia Lechmann
J Virol Methods.2022 Sep 8;310:114615.doi: 10.1016/j.jviromet.2022.114615

Adeno-associated virus type 2 (AAV2) uncoating is a stepwise process and is linked to structural reorganization of the nucleolusSereina O. Sutter, Anouk Lkharrazi, Elisabeth M. Schraner, Kevin Michaelsen, Anita Felicitas Meier, Jennifer Marx, Bernd Vogt, Hildegard Büning, Cornel Fraefel
PLoS Pathog. 2022 Jul 11;18(7):e1010187.doi: 10.1371/journal.ppat.1010187. Online ahead of print.

Display of Heterologous Proteins in Bacillus Subtilis Biofilms for Enteric Immunization
Claudio Aguilar, Ramona Wissmann, Cornel Fraefel, Catherine Eichwald
Methods Mol Biol. 2022:2465:73-95. doi: 10.1007/978-1-0716-2168-4_4

Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranesJosé L Martínez, Catherine Eichwald, Elisabeth M Schraner , Susana López , Carlos F Arias
Virology. 2022 Apr;569:29-36.doi: 10.1016/j.virol.2022.02.005. Epub 2022 Feb 26.

Defeating the COVID-19 pandemic with bacterial biofilms
Catherine Eichwald, Cornel Fraefel, Claudio Aguilar
Vierteljahrsschrift, 275 Jahre NGZH, 2/2021, der Naturfoschende Gesellschaft in Zürich

Budding and fusion in herpesvirus morphogenesis and transport
Peter Wild, Elisabeth M. Schraner, Mathias Ackermann
Current Topics in Virology, Volume 17, 2020

In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of PseudoparticlesStuart Sims, Kevin Michaelsen, Sara Burkhard, Cornel Fraefel
Advances in Virology Volume 2021, Article ID 5569844, https://doi.org/10.1155/2021/5569844

Herpes Simplex Virus 1 Coinfection Modifies Adeno-associated Virus Genome End Recombination.Meier AF, Tobler K, Michaelsen K, Vogt B, Henckaerts E, Fraefel C.
J Virol. 2021 Jun 10;95(13):e0048621. doi: 10.1128/JVI.00486-21

Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genomeAnita Felicitas Meier, Kurt Tobler, Remo Leisi, Anouk Lkharrazi, Carlos Ros, Cornel Fraefel
PLoS Pathog. 2021 Jun 1;17(6):e1009638. doi: 10.1371/journal.ppat.1009638

The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication CompartmentsSeyffert M., Georgi F., Tobler K., Bourqui L., Anfossi M. Michaelsen K., Vogt B., Greber U.F., Fraefel C.
Int.J.Mol. Sci. 2021 Apr 24;22(9):4447

Intermembrane distances at the feto-maternal interface inepitheliochorial placentation
Karl Klisch, Elisabeth M. Schraner
Placenta. 2021 Apr 24;109:37-42. doi: 10.1016/j.placenta.2021.04.011.

The Interplay between Adeno-Associated Virus and its Helper Viruses
Anita F. Meier, Cornel Fraefel, Michael Seyffert
Viruses. 2020 Jun 19;12(6):662.doi: 10.3390/v12060662.

Mammalian orthoreovirus core protein μ2 reorganizes host microtubule-organizing center componentsCatherine Eichwald, Mathias Ackermann, Cornel Fraefel
Virology (2020), doi: https:// doi.org/10.1016/j.virol.2020.07.008.

Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in miceChen Rong, Hornemann Thorsten, Stefanic Sasa, Schraner Elisabeth,
Züllig Richard, Reding Theresia, Malagola Ermanno, Henstridge Darren C, Hills Andrew P, Graf Rolf, Sonda Sabrina
2020 May 8. doi: 10.1007/s00125-020-05156-x. [Epub ahead of print]

Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm
Buttafuoco A, Michaelsen K, Tobler K, Ackermann M, Fraefel C, Eichwald C
J Virol. 2020 Jan 8. pii: JVI.01965-19. doi: 10.1128/JVI.01965-19

HSV-1 Amplicon Vectors as Genetic Vaccines
Meier A.F. , Laimbacher A.
Methods Mol Biol. 2020;2060:111-130. doi: 10.1007/978-1-4939-9814-2_6.

Intraluminal vesicles of binucleate trophoblast cell granules are a possible source of placental exosomes in ruminants
Karl Klisch, Elisabeth Schraner
Placenta 90 (2020) 58-61, doi.org/10.1016/j.placenta.2019.12.006