Publications 2020 -

Adeno-associated virus (AAV2) can replicate its DNA by a rolling Hairpin or rolling circle mechanism, depending on the helper virus.
Anouk Lkharrazi, Kurt Tobler, Sara Marti, Anna Bratus-Neuenschwander, Bernd Vogt, Cornel Fraefel
J Virol. 2024 Oct 09:e0097524.doi: 10.1128/jvi.01282-24

Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across
rotavirus species A to J
Melissa Lee, Ariana Cosic, Kurt Tobler, Claudio Aguilar, Cornel Fraefel, Catherine Eichwald
J Virol. 2024 Aug 28:e0097524.doi: 10.1128/jvi.00975-24
 

The interferon-γ inducible factor 16 (IFI16) restricts adeno-associated virus serotype 2 (AAV2) transduction in an immune-modulatory independent way
Sereina Sutter, Kurt Tobler, Michael Seyffert, Anouk Lkharrazi, Joël Zöllig, Elisabeth M. Schraner, Bernd Vogt, Hildegard Büning, Cornel Fraefel
J Virol 2024 Jul 23;98(7):e0011024. doi: 10.1128/jvi.00110-24
 

The Role of the Host Cytoskeleton in the Formation and Dynamics of Rotavirus Viroplasma
Janine Vetter, Melissa Lee, Catherine Eichwald
Viruses 2024, 16(5), 668; https://doi.org/10.3390/v16050668 (registering DOI)
 

The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
Janine Vetter, Guido Pap, Kurt Tobler, Javier M. Rodriguez, Manuel Kely, Michael Myers, Mahesa Wiesendanger, Elisabeth M. Schraner, Daniel Luque, Oscar R. Burrone, Cornel Fraefel, Catherine Eichwald
mBio2024 Vol. 15, No.4 Mar 12:e0049924.doi: 10.1128/mbio.00499-24

Genome Sequence of Alongshan Virus from Ixodes ricinus Ticks Collected in Switzerland

Stefanie Stegmüller, Cornel Fraefel, Jakuk Kubacki

Microbiol Resour Announc2023 Mar 16;12(3):e0128722.doi: 10.1128/mra.01287-22.

Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens

Stefanie Stegmüller, Weihong Qi, Paul R. Torgerson, Cornel Fraefel, Jakub Kubacki

PLoS One. 2023 Nov 13;18(11):e0290942.doi: 10.1371/journal.pone.0290942. eCollection 2023.

Equine papillomavirus type 2-associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding

Lale Dilara, Geyer Antonia, Jindar Christoph, Cavalleri Jessika-Maximiliane V., Ramsauer Anna Sophie

Veterinary Record Case Reports; doi 10.1002/vrc2.508

Cellular state landscape and herpes simplex virus type 1 infection progression are connected

Maija Pietilä, Jana J. Bachmann, Janne Ravantti, Lucas Pelkmans, Cornel Fraefel

Nat Commun. 2023 Jul 27;14(1):4515.doi: 10.1038/s41467-023-40148-6.

The Interplay between Adeno-Associated Virus and its Helper Viruses

Anita F. Meier, Cornel Fraefel, Michael Seyffert

Viruses. 2020 Jun 19;12(6):662.doi: 10.3390/v12060662.

Mammalian orthoreovirus core protein μ2 reorganizes host microtubule-organizing center components

Catherine Eichwald, Mathias Ackermann, Cornel Fraefel

Virology (2020), doi: https:// doi.org/10.1016/j.virol.2020.07.008.

Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice

Chen Rong, Hornemann Thorsten, Stefanic Sasa, Schraner Elisabeth,
Züllig Richard, Reding Theresia, Malagola Ermanno, Henstridge Darren C, Hills Andrew P, Graf Rolf, Sonda Sabrina

2020 May 8. doi: 10.1007/s00125-020-05156-x. [Epub ahead of print]

Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm

Buttafuoco A, Michaelsen K, Tobler K, Ackermann M, Fraefel C, Eichwald C

J Virol. 2020 Jan 8. pii: JVI.01965-19. doi: 10.1128/JVI.01965-19

HSV-1 Amplicon Vectors as Genetic Vaccines

Meier A.F. , Laimbacher A.

Methods Mol Biol. 2020;2060:111-130. doi: 10.1007/978-1-4939-9814-2_6.

Intraluminal vesicles of binucleate trophoblast cell granules are a possible source of placental exosomes in ruminants

Karl Klisch, Elisabeth Schraner

Placenta 90 (2020) 58-61, doi.org/10.1016/j.placenta.2019.12.006

Defeating the COVID-19 pandemic with bacterial biofilms

Vierteljahrsschrift, 275 Jahre NGZH, 2/2021, der Naturfoschende Gesellschaft in Zürich

Budding and fusion in herpesvirus morphogenesis and transport
Peter Wild, Elisabeth M. Schraner, Mathias Ackermann

Current Topics in Virology

In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of Pseudoparticles

Stuart Sims, Kevin Michaelsen, Sara Burkhard, Cornel Fraefel
Volume 2021, Article ID 5569844, https://doi.org/10.1155/2021/5569844

Herpes Simplex Virus 1 Coinfection Modifies Adeno-associated Virus Genome End Recombination.

Meier AF, Tobler K, Michaelsen K, Vogt B, Henckaerts E, Fraefel C. J Virol. 2021 Jun 10;95(13):e0048621. doi: 10.1128/JVI.00486-21

Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome

Anita Felicitas Meier, Kurt Tobler, Remo Leisi, Anouk Lkharrazi, Carlos Ros, Cornel Fraefel
PLoS Pathog. 2021 Jun 1;17(6):e1009638. doi: 10.1371/journal.ppat.1009638

The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments

Seyffert M., Georgi F., Tobler K., Bourqui L., Anfossi M. Michaelsen K., Vogt B., Greber U.F., Fraefel C.
Int.J.Mol. Sci. 2021 Apr 24;22(9):4447

Equine sarcoids in captive wild equids: Diagnostic and clinical management of 16 cases - a possible predisposition of the European cohort of Somali wild ass (Equus Africanus Somaliensis)?

Christian Wenker, Stefan Hoby, Beatrice L Steck, Anna Sophie Ramsauer, Sohvi Blatter, Kurt Tobler

J. Zoo Wildl Med. 2021 Apr;52(1):28-37.doi: 10.1638/2020-0166.

Intermembrane distances at the feto-maternal interface inepitheliochorial placentation

Karl Klisch, Elisabeth M. Schraner
Placenta. 2021 Apr 24;109:37-42. doi: 10.1016/j.placenta.2021.04.011.

TiO₂ nanoparticles abrogate the protective effect of the Crohn's disease-associated variation within the PTPN22 gene locus

Marlene Schwarzfischer, Anna Niechcia, Kristina Handler, Yasser Morsy^, Marcin Wawrzyniak , Andrea S Laimbacher , Kirstin Atrott , Roberto Manzini, Katharina Baebler, Larissa Hering, Egle Katkeviciute, Janine Häfliger, Silvia Lang, Maja E Keller, Jérôme Woodtli, Lisa Eisenbeiss, Thomas Kraemer, Elisabeth M Schraner, Mahesa Wiesendanger, Sebastian Zeissig, Gerhard Rogler, Andreas E Moor, Michael Scharl, Marianne R Spalinger

Gut.2022 Oct 3;gutjnl-2021-325911.doi: 10.1136/gutjnl-2021-325911.

Fully automated dried blood spot sample handling and extraction for BoHV-1 antibody testing by ELISA
Julia Lechmann, Oliver Gehrig, Marc Luginbühl, Cornel Fraefel, Stefan Gaugler

J Virol Methods.2022 Sep 28;310:114626.doi:10.1016/j.jviromet.2022.114626.

Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments

Janine Vetter, Guido Papa, Michael Seyffert, Kapila Gunasekera, Giuditta De Lorenzo, Mahesa Wiesendanger, Jean-Louis Reymond, Cornel Fraefel, Oscar R Burrone, Catherine Eichwald

J Virol. 2022 Sep 14;96(17):e0107422.doi: 10.1128/jvi.01074-22. Epub 2022 Aug 8.

Multiplex real-time PCR for the detection and differentiation of equid gammaherpesvirus 2 and 5

Flavia Fürer, Cornel Fraefel, Julia LechmannJ Virol Methods.2022 Sep 8;310:114615.doi: 10.1016/j.jviromet.2022.114615

Adeno-associated virus type 2 (AAV2) uncoating is a stepwise process and is linked to structural reorganization of the nucleolus

Sereina O. Sutter, Anouk Lkharrazi, Elisabeth M. Schraner, Kevin Michaelsen, Anita Felicitas Meier, Jennifer Marx, Bernd Vogt, Hildegard Büning, Cornel Fraefel

PLoS Pathog. 2022 Jul 11;18(7):e1010187.doi: 10.1371/journal.ppat.1010187. Online ahead of print.

Display of Heterologous Proteins in Bacillus Subtilis Biofilms for Enteric Immunization

Claudio Aguilar, Ramona Wissmann, Cornel Fraefel, Catherine Eichwald

Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes

 José L Martínez, Catherine Eichwald, Elisabeth M Schraner , Susana López , Carlos F Arias; Virology. 2022 Apr;569:29-36.doi: 10.1016/j.virol.2022.02.005. Epub 2022 Feb 26.