Publications 2008 - 2013

Viral and Cellular Components of AAV2 Replication Compartments.

Vogel R, Seyffert M, Pereira Bde A, Fraefel C.

Open Virol J. 2013 Oct 31;7:98-120. doi: 10.2174/1874357901307010098. eCollection 2013.

Optimizing glioblastoma temozolomide chemotherapy employing lentiviral-based anti-MGMT shRNA technology.

Viel T, Monfared P, Schelhaas S, Fricke IB, Kuhlmann MT, Fraefel C, Jacobs AH.Mol Ther. 2013 Mar;21(3):570-9. doi: 10.1038/mt.2012.278. Epub 2013 Jan 15.PMID: 23319055 [PubMed - in process]

Rotavirus viroplasm fusion and perinuclear localization are dynamic processes requiring stabilized microtubules.

Eichwald C, Arnoldi F, Laimbacher AS, Schraner EM, Fraefel C, Wild P, Burrone OR, Ackermann M.
PLoS One. 2012;7(10):e47947. doi: 10.1371/journal.pone.0047947. Epub 2012 Oct 23.PMID: 23110139 [PubMed - in process

Transcriptional targeting of DCs with lentiviral vectors induces antigen-specific tolerance in a mouse model of multiple sclerosis.
de Andrade Pereira B, Fraefel C, Hilbe M, Ackermann M, Dresch C.
Gene Ther. 2012 Sep 6. doi: 10.1038/gt.2012.73. [Epub ahead of print]

Gene delivery using helper virus-free HSV-1 amplicon vectors.
Laimbacher AS, Fraefel C, .
Curr Protoc Neurosci. 2012 Jul;Chapter 4:Unit 4.14.PMID: 22752894 [PubMed - in process]

HSV-1 Amplicon Vectors Launch the Production of Heterologous Rotavirus-like Particles and Induce Rotavirus-specific Immune Responses in Mice.

Laimbacher AS, Esteban LE, Castello AA, Abdusetir Cerfoglio JC, Argüelles MH, Glikmann G, D'Antuono A, Mattion N, Berois M, Arbiza J, Hilbe M, Schraner EM, Seyffert M, Dresch C, Epstein AL, Ackermann M, Fraefel C.
Mol Ther. 2012 Jun 19. doi: 10.1038/mt.2012.108. [Epub ahead of print]

Construction and packaging of herpes simplex virus/adeno-associated virus (HSV/AAV) Hybrid amplicon vectors.

Saydam O, Glauser DL, Fraefel C.
Cold Spring Harb Protoc. 2012 Mar 1;2012(3):352-6. doi: 10.1101/pdb.prot068114.

Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37.

Kelly BJ, Diefenbach E, Fraefel C, Diefenbach RJ.
Biochem Biophys Res Commun. 2012 Jan 20;417(3):961-5. Epub 2011 Dec 19.

Identification of a single amino acid residue which is critical for the interaction between HSV-1 inner tegument proteins pUL36 and pUL37.

Kelly BJ, Mijatov B, Fraefel C, Cunningham AL, Diefenbach RJ.
Virology. 2012 Jan 20;422(2):308-16. Epub 2011 Nov 21.

Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.

Vogel R, Seyffert M, Strasser R, de Oliveira AP, Dresch C, Glauser DL, Jolinon N, Salvetti A, Weitzman MD, Ackermann M, Fraefel C.J Virol. 2012 Jan;86(1):143-55. Epub 2011 Oct 19.

Thymic but not splenic CD8(+) DCs can efficiently cross-prime T cells in the absence of licensing factors.

Dresch C, Ackermann M, Vogt B, de Andrade Pereira B, Shortman K, Fraefel C.
Eur J Immunol. 2011 Jul 12. doi: 10.1002/eji.201041374. [Epub ahead of print]

Herpes Simplex Virus Type 1-Derived Recombinant and Amplicon Vectors.

Fraefel C, Marconi P, Epstein AL.
Methods Mol Biol. 2011;737:303-343.

Imaging herpes simplex virus type 1 amplicon vector-mediated gene expression in human glioma spheroids.

Kaestle C, Winkeler A, Richter R, Sauer H, Hescheler J, Fraefel C, Wartenberg M, Jacobs AH.
Mol Imaging. 2011 Jun;10(3):197-205. Epub 2011 Mar 1.

Bioluminescence imaging for in vivo monitoring of local recurrence mesothelioma model.

Shi Y, Hollenstein A, Felley-Bosco E, Fraefel C, Ackermann M, Soltermann A, Weder W, Stahel R, Pruschy M, Opitz I.
Lung Cancer. 2011 Mar;71(3):370-1. Epub 2011 Jan 31. No abstract available.

 HSV-1 amplicon vectors that direct the in situ production of foot-and-mouth disease virus antigens in mammalian cells can be used for genetic immunization.

D'Antuono A, Laimbacher AS, La Torre J, Tribulatti V, Romanutti C, Zamorano P, Quattrocchi V, Schraner EM, Ackermann M, Fraefel C, Mattion N.

Vaccine 2010 Oct 28;28(46):7363-72. Epub 2010 Sep 17.

[(18)F]FLT PET for Non-Invasive Monitoring of Early Response to Gene Therapy in Experimental Gliomas.

Rueger MA, Ameli M, Li H, Winkeler A, Rueckriem B, Vollmar S, Galldiks N, Hesselmann V, Fraefel C, Wienhard K, Heiss WD, Jacobs AH.
Mol Imaging Biol. 2010 Jun 19. (Epub ahead of print)

Glycoprotein D of Bovine herpesvirus 5 confers an extended host range to BoHV-1 but does not contribute to invasion of the brain.
Gabev E, Tobler K, Abril C, Hilbe M, Senn C, Franchini M, Campadelli-Fiume G, Frafel C, Ackermann M
J Virol. 84: 5583-5593 (2010)

Herpes simplex virus type 1/adeno-associated virus hybrid vectors.
de Oliveira A.P. and Fraefel C.
Open Virol. J. pp.109-122 (14), 2010

Inhibition of herpes simplex virus type 1 replication by adeno-associated virus Rep proteins depends on their combined DNA-binding and ATPase/helicase activities.

Glauser DL, Seyffert M, Strasser R, Franchini M, Laimbacher AS, Dresch C, de Oliveira AP, Vogel R, Büning H, Salvetti A, Ackermann M, Fraefel C.
J Virol. 84: 3808-3824 (2010)

Cloning of Bovine herpesvirus type 1 and type 5 as infectious bacterial artifical chromosomes.

Gabev E, Fraefel C, Ackermann M, Tobler K.
BMC Res Notes. 2009 Oct 14;2: 209

Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway.

Saydam O, Shen Y, Würdinger T, Senol O, Boke E, James MF, Tannous BA, Stemmer-Rachamimov AO, Yi M, Stephens RM, Fraefel C, Gusella JF, Krichevsky AM, Breakefield XO.
Mol Cell Biol. 2009 Nov;29(21):5923-40. Epub 2009 Aug 24

Definition of herpes simplex virus type 1 helper activities for adeno-associated virus early replication events.

Alazard-Dany N, Nicolas A, Ploquin A, Strasser R, Greco A, Epstein AL, Fraefel C, Salvetti A.
PLoS Pathog. 2009 Mar;5(3):e1000340. Epub 2009 Mar 13.PMID: 19282980

Functional roles of the tegument proteins of herpessimplex virus type 1
Kelly B.J., Fraefel C., Cunningham A.L., Diefenbach R.J.
Virus Res. 145:173-186 (2009)

Live visualization of herpes simplex virus type 1 compartment dynamics.

de Oliveira AP, Glauser DL, Laimbacher AS, Strasser R, Schraner EM, Wild P, Ziegler U, Breakefield XO, Ackermann M, Fraefel C.
J Virol. 2008 May;82(10):4974-90. Epub 2008 Mar 12.PMID: 18337577

Herpes simplex virus type 1/adeno-associated virus hybrid vectors.
Fraefel C., D.L. Glauser, T. Heister, and M. Ackermann
In: Bertolotti, R. Progress in Gene Therapy. World Scientific Publishing. 2008